clinpgx-database

ClinPGx Database - Clinical Pharmacogenomics Database API

Skill Overview

The ClinPGx Database skill provides programmatic access to the ClinPGx (the successor to PharmGKB) pharmacogenomics database. It allows querying gene-drug interactions, CPIC clinical guidelines, allele function, and drug label information to support precision medicine and genotype-guided prescribing decisions.

Use Cases

Clinical decision support for prescribing: Clinicians can query a patient's genotype and drug interactions before prescribing, obtain dosing adjustment recommendations based on CPIC guidelines, and avoid adverse drug reactions.

Pharmacogenomics research: Researchers can access authoritative gene-drug pair data, clinical annotations, and allele frequency information to conduct precision medicine research or drug development.

Interpretation of genetic test reports: Laboratories or clinical organizations can use the PharmDOG tool to interpret patients' pharmacogenomic test results and generate clinically actionable recommendation reports.

Core Features

Gene and drug queries: Supports querying interactions between hundreds of pharmacogenes (e.g., CYP450 enzyme family, TPMT, DPYD, HLA, etc.) and thousands of drugs, obtaining clinical annotations and evidence-level information.

CPIC guideline access: Direct access to CPIC clinical practice guidelines, including genotype-specific prescribing recommendations, strength-of-evidence ratings, and supporting literature, suitable for clinical decision support.

Allele and variant information: Query allele functional status (normal, decreased, no function, increased), population frequency data, and clinical significance annotations for specific variant sites.

FAQ

What is the difference between ClinPGx and PharmGKB?

ClinPGx is the official successor to PharmGKB. In July 2025 it integrated data from PharmGKB, CPIC, and PharmCAT. All PharmGKB URLs now redirect to the corresponding ClinPGx pages. ClinPGx provides a more unified API and updated pharmacogenomics data.

Is the ClinPGx API paid?

The ClinPGx API is provided under the Creative Commons Attribution-ShareAlike 4.0 International license. Basic access requires no authentication and is free. The API is rate-limited to a maximum of 2 requests per second; for high-volume use please contact api@clinpgx.org to notify the team.

What does ClinPGx data include?

ClinPGx integrates data from multiple authoritative sources, including: gene and drug information, gene-drug pairings, CPIC and DPWG clinical guidelines, drug labels from agencies such as the FDA and EMA, allele definitions and frequencies, clinical annotations (graded by evidence level), drug metabolism pathways, and more. The data is continuously updated and covers clinically relevant pharmacogenomics knowledge.