adaptyv

Adaptyv - Cloud-based Protein Experiment Automation and Validation Platform

Overview

Adaptyv is a cloud laboratory platform that lets you submit protein sequences via API for automated experimental validation, returning professional test results for binding experiments, expression tests, thermal stability, and enzyme activity in about 21 days.

Applicable Scenarios

1. Wet-lab validation for AI protein design

When you design protein sequences using AI models (such as AlphaFold, RFdiffusion), real-world experimental data are needed to verify whether the designs meet expectations. Adaptyv provides a full suite of protein assays, including binding affinity, expression level, and thermal stability, enabling experimental validation of computationally designed proteins.

2. Protein sequence optimization and expression improvement

During protein design, you may encounter issues like low solubility, insufficient expression, or poor stability. Adaptyv integrates computational tools such as NetSolP, SolubleMPNN, and ESM to help you optimize sequences before submission, increasing experimental success rates and saving time and cost.

3. High-throughput protein screening and testing

If you need to test multiple protein variants or candidate molecules simultaneously, Adaptyv’s cloud lab architecture supports batch experiment submission and automated processing via API, greatly improving screening efficiency—ideal for iterative optimization in drug discovery and protein engineering projects.

Core Features

1. Multiple types of protein assays

Supports binding experiments (biolayer interferometry, BLI), expression testing, thermal stability analysis, and enzyme activity assays. You only need to submit the protein sequence and experiment type; the platform will carry out the experimental workflow and return a professional data report in about 21 days.

2. API-driven experiment submission and management

Submit protein sequences, select experiment types, and set webhook callbacks via a RESTful API to track experiment status in real time. Supports batch processing of multiple sequences and integration into automated workflows—complete the end-to-end process from sequence submission to result download without manual intervention.

3. Integrated protein sequence optimization toolset

Before submitting experiments, the platform offers computational tools to help optimize sequences: NetSolP/SoluProt for solubility pre-screening, SolubleMPNN for redesign to improve solubility, ESM for sequence plausibility assessment, ipTM for analyzing interface stability, and pSAE for quantifying hydrophobic exposure. These tools can increase expression success rates and experiment quality.

Frequently Asked Questions

How long do Adaptyv experiment results take?

From sequence submission to receiving results typically takes about 21 days. The platform will notify you of progress via webhook, and you can also query current status via the API at any time. The turnaround is faster than traditional labs because the platform optimizes automated workflows.

How do I apply for Adaptyv API access?

Adaptyv is currently in Alpha/Beta testing. Send an email to support@adaptyvbio.com to request API access. Once approved, you will receive an API key and can begin using the service by setting the ADAPTYV_API_KEY environment variable. The platform is compatible with the Python requests library for easy setup.

What protein experiment types does Adaptyv support?

Currently supports four main experiment types: binding experiments (biolayer interferometry to test protein–target interactions), expression testing (measuring protein expression levels), thermal stability analysis (protein thermal denaturation characteristics), and enzyme activity assays (evaluating catalytic function). For more experiment types and detailed procedures, please refer to the platform’s experimental documentation.